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As a result of their ability to secrete substances that can activate the immune system, mast cells play a crucial role in immunity. Extreme allergic reactions are brought on by mast cells releasing their substances too frequently and often, as seen in patients with Mast Cell Activation Syndrome (MCAS).
Mast cells, upon recognizing an allergen, release chemicals known as mediators. When this happens, the body responds with inflammation, similar to what happens during an allergic reaction, and this inflammation ultimately aids in the healing process.
However, in those who suffer from MCAS, mast cells become overactive and trigger severe allergic reactions.
The accumulation of genetically altered mast cells and/or the abnormal release of these cells’ mediators characterizes mast cell activation disease, which can affect the functioning of virtually any organ system. Mast cell activation disease can usually be diagnosed with minimally invasive tests. Antihistamines and compounds that stabilize the membranes of mast cells are often all that is needed for effective treatment, with other drugs used to treat specific symptoms and complications as needed. Patients with chronic multisystem polymorbidity or those in whom a definitively diagnosed major illness does not well account for the entirety of the patient’s presentation should have mast cell activation disease included in their differential diagnosis on a regular basis, as it is now understood to likely be considerably prevalent.
ASIN : B0C1P511GN
Publication date : April 5, 2023
Language : English
File size : 377 KB
Simultaneous device usage : Unlimited
Text-to-Speech : Enabled
Screen Reader : Supported
Enhanced typesetting : Enabled
X-Ray : Not Enabled
Word Wise : Enabled
Sticky notes : On Kindle Scribe
Print length : 10 pages